March, 2018: MEGASTROKE – International Stroke Collaborative
The study of more than half a million people around the world has identified 22 new genetic risk factors for stroke. There were 32 genetic variants – or 149 genes – identified as risk factors in the research, 11 are in biological areas not previously thought to contribute to stroke. Drugs on the market are already targeting 16 genes in the management of other diseases such as epilepsy which provided possibilities for further research into the use of these medications for stroke. Also discovered was a genetic link between haemorrhagic and ischemic strokes.
University of Helsinki
Social isolation was associated with a higher risk of AMI and stroke in models adjusted for demographics. Similar results were demonstrated with loneliness. In the fully adjusted model, social isolation but not loneliness was associated with increased mortality among those with a history of AMI and stroke. In other words. Isolated and lonely persons are at increased risk of AMI and stroke, and, among those with a history of AMI or stroke, increased risk of death.
February, 2018: Brigham and Women’s Hospital - Boston
A study reports that 55,000 more women have strokes than men each year in the US. It is the leading cause of disability and the third leading cause of death in women. Risk factors unique to women are:
Menstruation before age 10
Menopause before age 45
Low levels of the hormone dehydroepiandrosterone (DHEAS)
Use of birth control pills.
History of pregnancy complications
While the risk factors are common, women should be made aware that they are at higher risk and be motivated to adhere to healthy life style behaviors to decrease risk of high blood pressure.
American Stroke Association
ASA is lobbying for the preservation of a number of rehabilitation extenders at risk in the current budget for Medicare. This includes therapy caps placing limits on treatment options for treatments medically necessary over the cap amounts. Also, telestroke services are only reimbursable in rural settings while 94% of stroke occur in urban settings. Supervision of cardio and pulmonary rehab currently needs to be overseen by a physician. ASA would like to see this go to PAs, NPs and clinical nurse specialists which would increase participation by increasing access to services.
January, 2018: Please read this month’s blog for important news regarding new Stroke Treatment Guidelines – game changing treatment methodology.
Rush University Medical Center – Chicago
A study of 106 stroke survivors over 4.7 years examined for cognitive decline including one’s ability to think, reason and remember while adhering to the MIND diet – Mediterranean-DASH Intervention for Neuordegenerative Delay. Participants were grouped according to adherence to the diet and examined for other factors known to affect cognitive performance including age, gender, education, participation in cognitive stimulating activities, physical activities, smoking and genetics. The findings were:
- Those who adhered most closely to the diet, had a substantially slower rate of cognitive decline compared to those who adhered less rigorously.
- The estimated effect of the diet remained strong even after taking into account other factors.
- Adherence to the MIND diet appear to be better suited to overall brain health and preserving cognition that either the Mediterranean or DASH diet.
The MIND diet combines the Mediterranean and DASH diets but features nuts, beans, poultry, whole grains and moderate wine consumption. It limits red meats and red meat products, butter, trans fat margarines, cheese, sweets and pastries as well as fried and fast foods. Studies have found that folate, vitamin E, omega-3 fatty acids, carotenoids and flavonoids are associated slower rates of cognitive decline.
Caution is urged since this is a preliminary study and involves a relatively small number. Additionally, the study is observational and findings cannot be interpreted in a cause-and-effect relationship.
American Heart Association
Reporting at the International Stroke Conference, the AHA reported that only 1 out of 100 or 1% of stroke survivors actually take the recommended medical steps to restore their cardiovascular health and prevent recurrence. The seven steps to prevent recurrence are: increase activity, eat healthier, lose weight, avoid smoking, manage blood pressure, control cholesterol, and lower blood sugar levels.
The report, based on data from nearly 68,000 stroke survivors, showed that rates had increased for diabetes – 56%- and obesity – 39% since the late 1980”s. Poor diets rose from 14% in the late 80’s to over 50% today.
On the good side, rates of high blood pressure and high cholesterol are down since the 1980’s.
December 2017: News from Stanford University
Although they do not want to overpromise, an early phase study of 18 patients has shown some remarkable results. Transplanting stem cells into the cells that have survived just outside the stroke has resulted in resurrecting the circuits. They are able to pump out very powerful growth factors, molecules and proteins that enhance native mechanisms of recovery such as new synapses of neurons that are there, new blood vessels and a modulation of the immune system. Three quarters of the patients showed what is called “a meaningful recovery” over a period of six months and sustained it at 12 months.
These results have spurred a larger, multi-center, double-blind controlled study of 156 patient throughout the country. Results from this study should be available in about a year.
November 2017: News from American Stroke Association
New high blood pressure guidelines have been announced dropping 140/80 being considered hypertensive to 130/80. Association physicians state that by the time someone’s blood pressure is at 130/80, they have already doubled their risk for stroke, heart attack and other cardiac events.
Lifestyle modifications are key – shedding pounds, giving up fast food, exercise, watching salt intake and reducing stress.
News from the Journal of Endocrine Society
A study found that consuming two sugar- sweetened drinks a week could increase the risk of developing type 2 diabetes by 42% and just one a week could elevate blood pressure. They call for more research on this alarming study result.
October 2017: News from Mount Sinai, New York
A longitudinal study following patients 13 years, presents evidence that a single ischemic stroke continues to be associated with a gradual increase in disability over the long term. Stroke is traditionally seen as a discrete, monophasic event assumed to stabilize following the 3-6 month recovery period after the incident. The research did not indicate that participants who had strokes had any higher slope of increasing disability before the stroke than those who eventually do not have strokes. They further noted that stroke’s long term adverse effects leading to accelerated functional decline may be treatable.
News from the German Stroke Foundation
Post Stroke Depression (PSD) is experienced by about one third of all strokers usually three to six months afterwards. Symptoms include listlessness, feelings of guilt, sleep disorders and a generally gloomy mood that persists for at least two weeks. It can be caused to some extent by the effect of the stroke on the brain, but is made worse by the restrictions on the person’s lifestyle that often follow. Hormones may also play a part. It is important to know that this is treatable, usually temporary and there is a good chance of recovery.
News from University of Liverpool:
Examining a group of 915 post stroke patients, 95% of survivors had visual impairments relating to central or peripheral vision, eye movement abnormalities or visual perceptual defects.
- 24% had reduced clarity of vision (central visual acuity)
- 16% of those with a visual impairment developed a squint (ocular motility disorders)
- 68% had impairments in eye movement (ocular motility disorders)
- 52% suffered from Peripheral visual field loss
- 15% developed visual inattention which causes those afflicted to ignore everything on one side of their visual world
October 6, 2017: Study attributes stroke decline to prevention education
Interesting article citing a decline in strokes in Iowa of 33%. The Iowa Department of Public Health attributes this decline to more education on prevention; strengthening of stroke triage and care at the stroke centers in the state; changing EMS protocols to immediate transfer to centers with the highest level of care; and, developing and implementing a Stroke registry.
This is interesting in that it shows what comprehensive care and education can do to reduce what is primarily a preventable incident.
September 28, 2017: This is why more and more young people are having Strokes
Although contraceptive use and smoking have both been cited, this article cites the JAMA Neurology study findings that the prevalence of having three to five stroke risk factors has more than doubled for women under 45. These include hypertension, lipid disorders – high cholesterol – diabetes, tobacco use and obesity. Older adults tend to manage these risk factors and the result I a decline in strokes in older adults.
August 2017: Does Diet Soda raise the Risk of Stroke?
In the Harvard Heart Letter, they take a look at the reports that have been put out linking Strokes to drinking Diet Soda. Review of the studies indicate no provable cause and effect link to stroke and diet soda. In a 2012 study following 127,000 people for more than 2 decades, there was a slightly higher risk of stroke in those who drank more than one soda a day – diet or regular. However, there was no higher stroke risk from sugary beverages even though many studies have demonstrated regular dinking of sugary beverages can lead to weight gain, diabetes, heart disease and stroke.
The Framingham Heart Study releases 2017 reported that people drinking at least one artificially sweetened soda a day compared with less than one a week were twice as likely to have a stroke. Explanations for this finding include survival bias which opines that people who drink sugary beverages may have died earlier from other diseases such as heart disease. Conversely, diet drinks may be linked because of a different issue called reverse causation. Overweight and diabetic patients may be more likely to choose diet drinks. The heightened stroke risk may come from those health problems.
July 7, 2017: Family Rehab proves ineffective
Interesting study in India states that even trained family members prove to be ineffective caretakers of stroke patients at home. The study looked at physiotherapy and occupational therapy at home finding that the degree of recovery or improvement in quality of life issues was not as expected.
This study supports the need for on-going professional help to recover from strokes – difficult to obtain throughout the world.
July 2, 2017: More Millennials are having Strokes
Research from the CDC indicates strokes among those 18-34 years of age have increased 34% in women and 15% in men. There is also a reported statistically significant increase for young adults in Mid-West and Western cities of over 1mm in population. (the so called “Stroke Belt” is the Southeast). In Western Cities between 2003 and 2012 strokes rose by 85% while rising 34% Mid-Western cities in the same time frame.
There appears to be not one explanation for the numbers but it is posited that obesity and inactivity along with diabetes may have greater impact in younger stroke victims. Drug usage likely plays a role as wee. Better imaging and detection does not account for all the difference – if this were the case we would see increases across all age groups when in fact the total numbers nationwide are declining. The urban bias may be influenced by the closure of many rural facilities reducing access to care. The data was also not adjusted for racial disparities – more African Americans have strokes than the general population.
June 29, 2017: The Obesity Paradox
Examining participant’s BMI in the Framington Heart Study, a comparison to those not experiencing a stroke indicated that those above a healthy bodyweight had higher survival rates from those in the normal range for bodyweight. Analysis controlled factors such as smoking, hypertension and diabetes.
This “Obesity Paradox” is reported in both CV disease and Diabetes as well as Stroke and may be the result of reverse causality – an individual’s weight may be reflective of illness or the health deteriorating effect of under nutrition in non-overweight subjects may contribute. Yet another explanation posits that imminent death may have a causal relationship to weight loss. While obesity remains a critical risk factor for CV and metabolic disease.
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Neuro Vitality Center
formerly the stroke recovery center